Determination of nucleoside DOT1L inhibitors’ residence times by τRAMD simulations

Residence times of receptors in dendritic spines analyzed by stochastic simulations in empirical domains.

Analysis of high-density superresolution imaging of receptors reveals the organization of dendrites at nanoscale resolution. We present here an apparently novel method that uses local statistics extracted from short-range trajectories for the simulations of long-range trajectories in empirical live cell images. Based on these empirical simulations, we compute the residence time of a receptor in...

Transient residence and exposure times

The residence time measures the time spent by a water parcel or a pollutant in a given water body and is therefore widely used in environmental studies. The adjoint method introduced by Delhez et al. (2004) to compute this diagnostic is revised here to take into account the effect of the initialization and of the boundary conditions. In addition to the equation for the mean residence time, it i...

Correlations in the sequence of residence times.

Sequences of residence times (RTs) associated with the escape from metastable states are observed in many fields. Here we study analytically and numerically the correlations among RTs for a bistable stochastic system driven by dichotomous noise. Our theory predicts an oscillatory behavior of the correlations with respect to the lag between RTs. Correlations vanish at all lags if the switching r...

Nucleoside Reverse Transcriptase Inhibitors

Although the incidence of HIV infection among women is increasing, the proportion of women in clinical trials that evaluate interventions for the treatment of HIV infection and its complications has historically been lower than the proportion of women in the HIV/AIDS patient population. Therefore, most knowledge about the efficacy of antiretroviral drugs and the adverse reactions associated wit...

Inhibition of Nucleoside Transport by p38 MAP Kinase Inhibitors